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Pulmonary carcinosarcoma in a cat
Gabriele Ghisleni1, Valeria Grieco, Marcello Mazzotti
1Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Università degli Studi di Milano, via Celoria 10, 20133 Milano, Italy.
Summary
A rare primary pulmonary carcinosarcoma was diagnosed in a cat presenting with respiratory distress. This study details the first reported case in felines, highlighting its distinct neoplastic components and metastatic potential.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Pulmonary carcinosarcoma is a rare but recognized tumor in human medicine.
- This case represents the first documented instance of primary pulmonary carcinosarcoma in a feline patient.
Observation:
- A Domestic Shorthaired cat exhibited severe respiratory distress and coughing.
- Thoracic radiographs showed a lobar mass and multiple cavitated intrapulmonary masses.
- Necropsy and histological examination revealed a biphasic tumor with bronchial adenocarcinoma and sarcomatous components.
Findings:
- Immunohistochemistry confirmed simultaneous expression of vimentin and cytokeratin in neoplastic cells.
- Diagnosis of primary pulmonary carcinosarcoma with intrapulmonary epithelial metastases was established.
- The tumor exhibited distinct epithelial and sarcomatous neoplastic components.
Implications:
- This case expands the known spectrum of pulmonary neoplasms in cats.
- Understanding feline pulmonary carcinosarcoma may inform comparative oncology research.
- Further investigation is warranted to determine the incidence and behavior of this rare feline tumor.