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Three new cytotoxic sesterterpenes from a marine sponge Spongia sp
Sachiko Tsukamoto1, Shunsuke Miura, Rob W M van Soest
1Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan. sachiko@p.kanazawa-u.ac.jp
Journal of Natural Products
|March 29, 2003
Abstract:
Three new sesterterpenes (1-3) were isolated from a marine sponge of the genus Spongia, and their structures were determined on the basis of spectroscopic analysis. The compounds 1-3 exhibited cytotoxicity against HeLa cells with IC(50) values of 19.5, 15.0, and 5.3 microg/mL, respectively.