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Immunoglobulins and immunoglobulin subclasses in the elderly.
1Immunology and Immunogenetics, North Bristol NHS Trust, Southmead Hospital, Bristol BS10 5NB, UK.
Annals of Clinical Biochemistry
|March 29, 2003
Summary
Immunoglobulin (Ig) levels, including IgG subclasses, decline in the elderly, differing from adult reference ranges. New reference ranges are needed for this population to ensure accurate diagnostics.
Area of Science:
- Immunology
- Geriatric Medicine
- Clinical Chemistry
Background:
- Established immunoglobulin (Ig) reference ranges may not apply to the elderly.
- Limited data exists for IgG subclasses in older adults.
- This study addresses the need for age-specific Ig data in the elderly.
Purpose of the Study:
- To establish reference ranges for IgG, IgA, IgM, and IgG subclasses in an elderly UK population.
- To compare Ig levels in elderly individuals with younger adults.
- To identify age- and gender-related differences in immunoglobulin concentrations.
Main Methods:
- Serum samples from 1146 patients over 60 and 925 aged 18-60 were analyzed for Igs.
- Serum samples from 498 patients over 60 and 484 aged 18-60 were analyzed for IgG subclasses.
- Immunoglobulins and subclasses were quantified using nephelometry, with reference ranges determined by probability plotting.
Main Results:
- Median serum IgG and IgM concentrations were significantly lower in the elderly.
- Serum IgA levels were maintained, with a slight increase observed in elderly men.
- Specific IgG subclasses showed reductions in the elderly, with IgG(2) lower in men and IgG in women.
Conclusions:
- Current adult immunoglobulin reference ranges are inadequate for the elderly population.
- Local, method-dependent reference ranges are recommended for accurate interpretation.
- The study provides essential data for establishing appropriate reference ranges for elderly patients.