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Related Experiment Videos

Dynamic Plasticity Influences the Emergence of Function in a Simple Cortical Array.

Mark H. Johnson1, Jeff Shrager

  • 1MRC Cognitive Development Unit, London, UK

Neural Networks : the Official Journal of the International Neural Network Society
|October 1, 1996
PubMed
Summary

A "wave of plasticity" during brain development enhances functional organization in later-developing cortical areas. This finding explains how developmental timing influences the structure of the cerebral cortex.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Biology

Background:

  • The functional organization of the cerebral cortex arises during brain development.
  • Understanding the factors driving this organization is crucial for neuroscience.

Purpose of the Study:

  • To investigate the factors contributing to the functional organization of the cerebral cortex.
  • To explore the role of developmental timing in cortical development.

Main Methods:

  • Computational experiments using a simplified cortical array model.
  • Simulating a dynamical spatial modulation of plasticity, termed a "wave of plasticity".

Main Results:

  • A wave of plasticity was shown to induce higher functional development in later-developing cortical regions.

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  • This mechanism provides a potential explanation for differential development across cortical areas.

    • Conclusions:

    • Dynamical changes in plasticity over space and time are key to cortical functional organization.
    • Altered developmental timing can account for the emergence of diverse cortical structures.