Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure-function correlations in patients with malformations of cortical development.

Alex R. Paciorkowski1, Trudy Lerer, Philip J. Brunquell

  • 1Department of Pediatrics, Division of Medical Education, Connecticut Children's Medical Center, 282 Washington Street, 06106, Hartford, CT, USA

Epilepsy & Behavior : E&B
|March 29, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing disease activity using the pediatric Crohn's disease activity index: Can we use subjective or objective parameters alone?

World journal of gastroenterology·2021
Same author

Biologics Delay Progression of Crohn's Disease, but Not Early Surgery, in Children.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2018
Same author

Back Pain in a Pediatric Emergency Department: Etiology and Evaluation.

Pediatric emergency care·2018
Same author

Symptom-Guided Emergency Department Discharge Instructions for Children With Concussion.

Pediatric emergency care·2017
Same author

Retrospective Comparison of Fluticasone Propionate and Oral Viscous Budesonide in Children With Eosinophilic Esophagitis.

Journal of pediatric gastroenterology and nutrition·2017
Same author

National trends and variability in blood utilization in paediatric cardiac surgery.

Interactive cardiovascular and thoracic surgery·2017

Malformations of cortical development (MCD) correlate with clinical disability. Greater MRI abnormality and overall EEG abnormality, particularly in lissencephaly, indicate more severe patient disability.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Clinical Neurology

Background:

  • Malformations of cortical development (MCD) present genetic and phenotypic heterogeneity.
  • Previous research focused on individual MCD types, lacking broad structure-function correlations.
  • A comprehensive analysis correlating clinical disability with neuroimaging and electrophysiologic findings across diverse MCDs is needed.

Purpose of the Study:

  • To correlate clinical disability with specific Magnetic Resonance Imaging (MRI) and Electroencephalography (EEG) findings in patients with MCD.
  • To investigate the relationship between the extent of cortical malformation and functional impairment.
  • To identify specific EEG features predictive of disability in MCD.

Main Methods:

  • Retrospective review of medical records for 22 patients diagnosed with MCD.

Related Experiment Videos

  • Correlation analysis between clinical disability scores and MRI findings (extent of abnormality).
  • Correlation analysis between clinical disability scores and EEG findings (background activity, epileptiform discharges, posterior rhythms, sleep features).

    • Main Results:

    • The extent of MRI-detected abnormality significantly correlated with clinical disability.
    • Patients with lissencephaly exhibited greater disability compared to those with other MCD lesions.
    • While specific EEG abnormalities were not individually predictive, overall EEG abnormality, posterior head rhythm alterations, and sleep feature changes significantly correlated with clinical disability.

    Conclusions:

    • Neuroimaging (MRI) and electrophysiologic (EEG) findings are significantly correlated with clinical disability in Malformations of Cortical Development.
    • The degree of structural abnormality on MRI and the overall complexity of EEG abnormalities are key indicators of functional impairment in MCD.
    • Lissencephaly represents a severe form of MCD with profound clinical disability, underscoring the importance of comprehensive assessment.