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Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats
Jason M Rall1, Sara A Mach, Pramod K Dash
1Department of Neurobiology and Anatomy, Neurosurgery, Vivian L. Smith Center for Neurologic Research, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225, USA.
Abstract:
Cyclooxygenase-2 (COX-2) inhibitors have been shown to block memory retention in rodents following Morris water maze training and in chicks following a passive avoidance task. However, the role of COX-2 in acquisition has not been analyzed. We show that pre-training intrahippocampal infusion of a COX-2 specific inhibitor (celecoxib) attenuated water maze acquisition. These findings, along with previously published reports, implicate COX-2 activity in both memory acquisition and retention.
