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Emergence of ciprofloxacin-resistant pseudomonas in pediatric otitis media

Chul Ho Jang1, See Young Park

  • 1Department of Otolaryngology, Wonkwang Medical School, Iksan 570-711, Republic of Korea. chul@wonkwang.ac.kr

International Journal of Pediatric Otorhinolaryngology
|March 29, 2003
PubMed

Insights

Fluoroquinolone resistance in pediatric otorrhea is increasing. Topical ciprofloxacin failed in patients with multidrug-resistant Pseudomonas aeruginosa, necessitating alternative antibiotics like amikacin and imipenem.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Widespread use of fluoroquinolone otic drops has led to increased resistance.
  • Fluoroquinolone resistance rates are higher than anticipated, impacting treatment efficacy.

Purpose of the Study:

  • To evaluate pediatric patients with recurrent otorrhea unresponsive to topical ciprofloxacin.
  • To identify causative pathogens and assess antibiotic susceptibility patterns.

Main Methods:

  • Retrospective review of 17 pediatric patients with refractory otorrhea between 2000 and 2001.
  • Culture and antibiotic sensitivity testing to determine pathogen resistance profiles.

Main Results:

  • All patients exhibited ciprofloxacin-resistant Pseudomonas aeruginosa on culture.
  • These resistant strains were multidrug-resistant.
  • Imipenem and amikacin showed the highest sensitivity rates.

Conclusions:

  • Increasing ciprofloxacin resistance in otitis media is a recent concern.
  • Culture and sensitivity testing are crucial for guiding management.
  • Continuous surveillance of antibiotic resistance is essential.
Abstract

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