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Type 2 diabetes in Asian-Indian urban children
Ambady Ramachandran1, Chamukuttan Snehalatha, Kumpatla Satyavani
1Diabetes Research Centre and MV Hospital for Diabetes, Royapuram, Chennai, India. ramachandran@vsnl.com
Objective:
Due to a background of high prevalence of type 2 diabetes and the increasing rate of obesity occurring in relatively young urban children, we felt the need to look for type 2 diabetes in children.
Research Design And Methods:
A study of cases of type 2 diabetes with age at diagnosis of
Results:
All children showed a response to ODAs, had good beta-cell reserve (>/=0.6 pmol/ml on stimulation), and negligible GAD(65) antibodies indicating the presence of type 2 diabetes. The children were nonketotic; nine were obese, four had acanthosis nigricans, and one had polycystic ovary syndrome. Positive family history of diabetes was present in all cases.
Conclusions:
The clinical, immunological, and biochemical profile showed that the children had type 2 diabetes. The profile of type 2 diabetes was similar to that described in children in many other countries. Although less common than type 1 diabetes, type 2 diabetes in children is a condition that needs to be recognized and looked for in Asian-Indians.