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Bone mineral density and stroke
Michael E Mussolino1, Jennifer H Madans, R F Gillum
1Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD 20782, USA.
Stroke
|March 29, 2003
Summary
Bone mineral density (BMD) does not predict stroke incidence or mortality in white or black adults. This large national study found no significant associations between BMD levels and stroke risk or death.
Area of Science:
- Gerontology
- Epidemiology
- Public Health
Background:
- Bone mineral density (BMD) is a key indicator of bone health.
- Previous research has explored various risk factors for stroke.
- The predictive value of BMD for cerebrovascular events requires further investigation.
Purpose of the Study:
- To evaluate the long-term predictive utility of bone mineral density (BMD) for stroke incidence.
- To assess the association between BMD and stroke mortality.
Main Methods:
- Utilized data from the First National Health and Nutrition Examination Survey (NHANES I).
- Followed a cohort of 3402 white and black adults (aged 45-74) from 1971-1992.
- Identified 416 stroke cases using hospital records and death certificates.
Main Results:
- No significant association was found between decreased BMD and stroke incidence across race-sex groups (white men, white women, blacks).
- Cox proportional-hazards analyses revealed no significant relative risk for stroke with lower BMD.
- BMD was not significantly associated with stroke mortality (RR, 1.03; 95% CI, 0.86 to 1.23).
Conclusions:
- This large-scale national study found no significant link between bone mineral density and stroke incidence or mortality in white or black populations.
- BMD may not be a reliable predictor for cerebrovascular events in these demographic groups.