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Related Experiment Videos

Polydipsia--a study in a long-term psychiatric unit.

Jose de Leon1

  • 1Mental Health Research Center at Eastern State Hospital and Department of Psychiatry, University of Kentucky, Lexington, KY 40508, USA. jdeleon@uky.edu

European Archives of Psychiatry and Clinical Neuroscience
|March 29, 2003
PubMed
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Polydipsia (excessive thirst) affects at least 20% of chronic psychiatric inpatients. Switching patients from clozapine to other antipsychotics may worsen polydipsia and hyponatremia, requiring caution.

Area of Science:

  • Psychiatry
  • Endocrinology

Background:

  • Polydipsia is a significant concern in chronic psychiatric inpatients.
  • This study reviews polydipsia in treatment-refractory patients within a US psychiatric hospital.

Observation:

  • A 5-year retrospective review (1996-2000) analyzed 61 patients admitted to a long-term unit.
  • Polydipsic patients were monitored using diurnal weight changes and other biological measures.

Findings:

  • Polydipsia impacts at least 20% of chronic psychiatric inpatients.
  • Hyponatremia (low sodium levels) was observed in over 10% of these patients.
  • Two patients experienced worsened polydipsia when switched from clozapine to other atypical antipsychotics.

Implications:

Related Experiment Videos

  • Polydipsia in severe mental illness is an under-recognized clinical challenge.
  • Caution is advised when switching polydipsic patients from clozapine to other atypical antipsychotics.
  • Further prospective studies are needed to evaluate clozapine's efficacy for polydipsia.