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[Analyses of EGF and TNF contents in fetal wound healing process]
Guoping Feng1, Guangci Sun, Zhengyu Guan
1Plastic Surgery Hospital of China Academy of Medical Science and Peking Union Medical College, Beijing 100041, China.
Objective:
To investigate the role of EGF and TNF in the fetal wound healing process.
Methods:
On a fetal wound healing model with the maternal rabbit on 22-23 days of pregnancy (term = 31-32 days), the contents of EGF and TNF were analyzed with a RIA kit, compared to the maternal rabbit group and the adult rabbit group.
Results:
The EGF and TNF contents in the fetal wound were both increasing 3 days after the operation and maintained in a high level until the 7th day of the wound healing process(P < 0.05). However, the EGF and TNF contents in the maternal and adult rabbit groups were only kept at a high level during the 3 days after the surgery.
Conclusion:
The results are indicated that the EGF and TNF may play an important role in fetal wound healing.