[Comparative findings concerning the effect of elenium and seduxen on the cardiovascular system]

The authors studied the effect of seduxen and elenium on 169 patients, particularly their pulse frequency, arterial pressure, electro- and polycardiogramms in a single administration of the drugs parenterally and in a long-term per os administration. A parenteral introduction of both drugs was accompanied by a slight bradycardial effect. However, high doses of seduxen (0.34--0.5 mg/kg) lead to states of tachycardia. Unlike elenium which did not exert a hypotensive effect, seduxen displayed a mild and in some cases significant hypotensive action.