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Related Experiment Videos

A system for MEA-based multisite stimulation.

Yasuhiko Jimbo1, Nahoko Kasai, Keiichi Torimitsu

  • 1NTT Basic Research Laboratories, NTT Corporation, Kanagawa 243-0198, Japan. jimbo@will.brl.ntt.co.jp

IEEE Transactions on Bio-Medical Engineering
|April 1, 2003
PubMed
Summary

This study introduces a novel microelectrode array system for precise, simultaneous stimulation and recording in neuronal networks. The system enables flexible site selection and rapid switching, advancing the study of neural signal processing.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Electrophysiology

Background:

  • Microelectrode arrays (MEAs) offer potential for multisite stimulation but face technical challenges.
  • Existing systems struggle with interference during simultaneous stimulation and recording.
  • Programmable multisite stimulation is crucial for advanced neuroscience research.

Purpose of the Study:

  • To develop a practical multisite stimulation and recording system for MEAs.
  • To enable flexible, PC-controlled switching between stimulation and recording at individual electrodes.
  • To minimize interference and allow simultaneous recording during stimulation.

Main Methods:

  • Integration of preamplifiers and transistor-transistor logic-driven solid-state switching devices into novel interface circuit modules.

Related Experiment Videos

  • Development of a PC-controlled system for remote switching of substrate electrodes.
  • Utilizing the system for stimulation and recording in cultured cortical neuron networks.

    • Main Results:

    • Achieved PC-controlled remote switching of each substrate electrode with flexible site selection.
    • Enabled rapid switching between stimulation and recording (within 1.2 ms) with minimal interference.
    • Successfully recorded whole-cell synaptic currents and visualized spatial propagation patterns of evoked responses.

    Conclusions:

    • The developed MEA system overcomes technical hurdles for practical multisite stimulation.
    • It facilitates almost continuous monitoring and flexible stimulation/recording.
    • This tool is valuable for studying neuronal signal processing and synaptic integration in biological networks.