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Related Experiment Videos

Two multichannel integrated circuits for neural recording and signal processing.

Iyad Obeid1, James C Morizio, Karen A Moxon

  • 1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. io@duke.edu

IEEE Transactions on Bio-Medical Engineering
|April 1, 2003
PubMed
Summary

Two novel analog CMOS neurochips were developed for neural recording. These custom integrated circuits effectively processed neural signals from densely packed electrode arrays in vivo.

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Area of Science:

  • Neuroscience
  • Electrical Engineering
  • Biomedical Engineering

Background:

  • Advancements in neural recording technologies are crucial for understanding brain function.
  • Integrated circuits offer miniaturization and high-density signal acquisition capabilities for neural interfaces.

Purpose of the Study:

  • To develop and characterize two analog CMOS neurochips for high-density neural electrode recording.
  • To evaluate the performance of these neurochips in vivo.

Main Methods:

  • Development and fabrication of two 16-channel analog CMOS integrated circuits (Device A and Device B).
  • Characterization of amplifier gain, noise performance, and filtering properties for both devices.
  • In vivo testing of the neurochips with electrode arrays implanted in the somatosensory cortex.

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Main Results:

  • Device A: 16-channel buffer with a mean gain of 1.99 V/V and 10 microV(rms) input noise.
  • Device B: 16-channel signal processor with selectable gains (250/500 V/V), high-pass filtering (211 Hz pole), and 4.4 microV(rms) input noise.
  • Successful in vivo demonstration of neural signal recording in the somatosensory cortex.

Conclusions:

  • The developed analog CMOS neurochips are suitable for high-density neural recording applications.
  • These custom integrated circuits provide effective signal processing for in vivo neural data acquisition.
  • The neurochips demonstrate promising performance for future brain-computer interfaces and neuroscience research.