Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monolithic triglyceride matrices: a controlled-release system for proteins.

W Vogelhuber1, E Magni, M Mouro

  • 1Department of Pharmaceutical Technology, University of Regensburg, Regensburg, Germany.

Pharmaceutical Development and Technology
|April 1, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Five-year recurrence after endoscopic approach to pilonidal sinus disease: A multicentre experience.

Techniques in coloproctology·2023
Same author

Short communications: an ear-attached accelerometer detects effects of regrouping on lying, rumination, and activity times in calves.

Veterinary research communications·2023
Same author

In vitro and in vivo evaluation of a pH-, microbiota- and time-based oral delivery platform for colonic release.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2022
Same author

Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems.

Journal of the mechanical behavior of biomedical materials·2021
Same author

Histology of human teeth: Standard and specific staining methods revisited.

Archives of oral biology·2021
Same author

Accuracy of the fluorescence-aided identification technique (FIT) for detecting tooth-colored restorations utilizing different fluorescence-inducing devices: an ex vivo comparative study.

Clinical oral investigations·2021
Same journal

<i>Camellia sinensis</i> Silver Nanoparticles Inhibit Proliferation and Induce PARP-Dependent Apoptosis in A549 Cells: Formulation, Characterization, and Biological Evaluation.

Pharmaceutical development and technology·2026
Same journal

Enhanced solubility and bioavailability of zanubrutinib nanocrystals: Physicochemical and Pharmacokinetic evaluation.

Pharmaceutical development and technology·2026
Same journal

Intradermal delivery of lidocaine hydrochloride using dissolving microneedles: <i>in vitro</i> dermatokinetic test and <i>in vivo</i> anesthetic activity assessment.

Pharmaceutical development and technology·2026
Same journal

Quality by design-guided development of silica-enabled lipid hybrid nanoparticles for enhanced olaparib dissolution.

Pharmaceutical development and technology·2026
Same journal

Surface engineering of nanocarriers with polymer coatings: materials, strategies, functional outcomes, and clinical translation.

Pharmaceutical development and technology·2026
Same journal

Compression equations in pharmaceutical tableting: from classical compaction models to data-driven and mechanistic approaches.

Pharmaceutical development and technology·2026
See all related articles

Glyceryl trimyristate matrices offer a promising injectable drug delivery system. These bioerodible matrices allow tunable release of model drugs, showing good stability for protein and peptide therapeutics.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Injectable drug delivery systems are crucial for sustained therapeutic agent release.
  • Biodegradable polymers are commonly used but can have limitations.
  • Triglyceride-based matrices present a potential alternative for parenteral drug delivery.

Purpose of the Study:

  • To investigate glyceryl trimyristate matrices as a bioerodible and biocompatible platform for parenteral drug delivery.
  • To evaluate the release kinetics of model compounds with varying molecular weights.
  • To assess the stability of proteins within these matrices and their in vivo performance.

Main Methods:

  • Manufacturing of glyceryl trimyristate matrices by compression.
  • In vitro drug release studies using pyranine (low molecular weight) and TAMRA-BSA (protein).

Related Experiment Videos

  • Assessment of protein stability using hyaluronidase and in vivo subcutaneous implantation in mice.

    • Main Results:

    • Drug release was significantly influenced by gelatin content, allowing tunable release from days to weeks.
    • Higher molecular weight compounds (TAMRA-BSA) exhibited more pronounced burst release.
    • Proteins demonstrated stability during manufacturing and in vitro, with matrices showing good in vivo stability for 15 days.

    Conclusions:

    • Glyceryl trimyristate matrices are a viable, bioerodible, and biocompatible option for parenteral drug delivery.
    • Matrix properties can be modulated to control drug release profiles.
    • Triglycerides represent a promising alternative to biodegradable polymers for protein and peptide drug delivery systems.