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Medium chain triglycerides as vehicle for palatable oral liquids
Surendra M Bahal1, Jamie M Romansky, Francisco J Alvarez
1Pharmaceutical Research & Development, Bristol-Myers Squibb Company, Wilmington, Delaware, USA.
Pharmaceutical Development and Technology
|April 1, 2003
Abstract:
Aqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.