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RNA-binding proteins that target the androgen receptor mRNA
Jackie A Wilce1, Peter J Leedman, Matthew C J Wilce
1Department of Biochemistry and Molecular Biology/Department of Chemistry, Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australia. jwilce@chem.uwa.edu.au
Abstract:
Recent efforts to elucidate mechanisms of posttranscriptional gene regulation have resulted in the description of both cis- and trans-acting factors which affect the stability and translational efficiency of specific mRNAs. Here we summarise some of the concepts in this field, with particular attention to recently discovered protein/RNA interactions involving the human androgen receptor mRNA. Such systems are of interest for their potential as targets for the modulation of protein production.