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Vasopressin tachyphylaxis. A study in conscious man
Acta Chirurgica Scandinavica
|January 1, 1976
Summary
Repeated infusions of lysine-8-vasopressin (LVP) lowered portal venous pressure and increased blood pressure in patients. However, tachyphylaxis, or reduced effectiveness, was noted in diastolic blood pressure and arterio-portal venous oxygen difference.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
- Gastroenterology
Background:
- Lysine-8-vasopressin (LVP) is a vasoactive hormone with potential therapeutic applications.
- Understanding LVP's hemodynamic effects and potential for tachyphylaxis is crucial for clinical use.
- Portal venous system dynamics are critical in liver disease and gastrointestinal circulation.
Purpose of the Study:
- To investigate the effects of continuous intravenous LVP infusion on hemodynamic parameters in conscious patients.
- To assess the development of tachyphylaxis during repeated LVP administration.
Main Methods:
- Conscious patients (n=12) received constant intravenous infusion of LVP via portal venous catheters.
- Hemodynamic parameters including portal venous pressure, arterio-portal venous oxygen difference, blood pressures, and heart rate were monitored.
- Tachyphylaxis was evaluated by observing changes in response over time.
Main Results:
- LVP infusion led to a decrease in portal venous pressure.
- Systolic and diastolic blood pressures increased, while heart rate decreased.
- Tachyphylaxis was observed in the arterio-portal venous oxygen difference and diastolic blood pressure, but not in portal venous pressure, systolic blood pressure, or heart rate.
Conclusions:
- LVP exhibits significant hemodynamic effects on the portal venous system and systemic circulation.
- The development of tachyphylaxis in specific parameters suggests a complex physiological response to sustained LVP infusion.
- Further research is warranted to optimize LVP administration and mitigate tachyphylaxis for therapeutic benefit.