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Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia
Roger L Albin1, Donna Cross, Wayne T Cornblath
1Geriatrics Research, Education Clinical Center, Ann Arbor VAMC and Department of Neurology, University of Michigan 41809-0585, USA. ralbin@umich.edu
Annals of Neurology
|April 1, 2003
Abstract:
Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.