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Total synthesis of (+)-macrosphelides A, C, E, F, and G based on enzymatic function
Hiroyuki Akita1, Hiroshi Nakamura, Machiko Ono
1Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan. akita@phar.toho-u.ac.jp
Chirality
|April 1, 2003
Abstract:
The total synthesis of (+)-macrosphelide A (1) (18.5% overall yield in 11 steps), (+)-macrosphelide C (2) (25% overall yield in 9 steps), (+)-macrosphelide E (3) (23.9% overall yield in 11 steps), (+)-macrosphelide F (4) (20% overall yield in 9 steps), and (+)-macrosphelide G (5) (22% overall yield in 9 steps) was achieved from a chemoenzymatic reaction product (4R,5S)-4-benzyloxy-5-hydroxy-2(E)-hexenoate 10.