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Related Experiment Videos

Cognitive functioning in patients with a small infarct in the brainstem.

Martine van Zandvoort1, Edward de Haan, Jan van Gijn

  • 1Psychological Laboratory, Helmholtz Institute, Utrecht University, The Netherlands. m.vanzandvoort@fss.uu.nl

Journal of the International Neuropsychological Society : JINS
|April 2, 2003
PubMed
Summary

Small white matter infarcts, regardless of location, can cause cognitive impairments. This study found similar cognitive deficits in brainstem infarct patients compared to those with supratentorial infarcts, suggesting a nonspecific effect on brain function.

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Area of Science:

  • Neurology
  • Neuropsychology

Background:

  • Small supratentorial white matter infarcts are associated with subtle cognitive impairments and difficulties in daily functioning.
  • Potential causes include bystander effects or long-distance neurochemical changes.

Purpose of the Study:

  • To investigate the cognitive effects of small brainstem lacunar infarcts.
  • To compare these effects with those of supratentorial white matter infarcts.

Main Methods:

  • Neuropsychological evaluation of 17 patients with brainstem lacunar infarcts.
  • Comparison with a matched control group.

Main Results:

  • Patients with brainstem infarcts showed significant impairments in cognitive tasks.
  • The pattern of cognitive deficits was similar to that observed in patients with supratentorial infarcts.

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Conclusions:

  • Small white matter infarcts can non-specifically affect cognitive functioning.
  • Cognitive impairment is independent of the infarct's location in the white matter.