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Expression-driven reverse engineering of targeted imaging and therapeutic agents.

Robert J Gillies, Victor J Hruby

    Expert Opinion on Therapeutic Targets
    |April 2, 2003
    PubMed
    Summary

    Targeting cancer

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    Frontiers in oncology·2022

    Area of Science:

    • Oncology
    • Pharmacogenomics
    • Molecular Biology

    Background:

    • Systemic cancer treatment necessitates targeting cellular phenotypes rather than tumor location.
    • Exploiting tumor metabolism and physiology has shown success in developing targeted therapies.
    • Molecular phenotyping, or pharmacogenomics, offers a novel approach to cancer treatment.

    Discussion:

    • Pharmacogenomics currently segments patients based on protein expression to guide existing therapies.
    • This communication proposes developing novel agents reverse-engineered to target specific patient protein patterns.
    • This approach aims to create highly personalized and effective cancer treatments.

    Key Insights:

    • Cancer's systemic nature requires targeting molecular phenotypes.
    • Pharmacogenomics enables patient stratification based on protein expression.
    • Reverse-engineering drugs to match patient protein profiles is a promising strategy.

    Outlook:

    • Advancements in pharmacogenomics will drive the development of therapies discriminating tumor from normal tissue metabolism.
    • Personalized medicine through molecular phenotyping holds significant promise for future cancer treatment.
    • Developing targeted agents based on individual protein expression patterns represents a new frontier in oncology.

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