Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bupropion SR for smoking cessation.

Robert West1

  • 1St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. r.west@sghms.ac.uk

Expert Opinion on Pharmacotherapy
|April 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study.

European journal of pharmacology·2017
Same author

Variations in achievement of evidence-based, high-impact quality indicators in general practice: An observational study.

PloS one·2017
Same author

Using Bayesian statistics in health psychology: a comment on Depaoli et al. (2017).

Health psychology review·2017
Same author

Associations between tobacco control mass media campaign expenditure and smoking prevalence and quitting in England: a time series analysis.

Tobacco control·2017
Same author

Developing and Evaluating Digital Interventions to Promote Behavior Change in Health and Health Care: Recommendations Resulting From an International Workshop.

Journal of medical Internet research·2017
Same author

What factors are associated with abstinence amongst socioeconomically disadvantaged smokers? A cross-sectional survey of use of cessation aids and quitting approach.

Drug and alcohol review·2017

Bupropion hydrochloride sustained-release is an effective medication for smoking cessation, improving long-term success rates by 9-10%. This smoking cessation aid offers a cost-effective solution for saving lives.

Area of Science:

  • Pharmacology
  • Public Health
  • Addiction Medicine

Background:

  • Cigarette dependence is a significant health risk.
  • Bupropion hydrochloride sustained-release is a licensed medication for smoking cessation.
  • Recommended dosage and treatment duration vary by country.

Purpose of the Study:

  • To evaluate the efficacy of bupropion hydrochloride sustained-release in aiding smoking cessation.
  • To assess the cost-effectiveness of bupropion hydrochloride sustained-release for life-year savings.

Main Methods:

  • Seven double-blind, placebo-controlled, randomized trials were analyzed.
  • Data on cessation and relapse patterns were considered.
  • Life-expectancy improvements in successful quitters were factored in.

Related Experiment Videos

Main Results:

  • Bupropion improves 12-month smoking cessation success by 9-10 percentage points.
  • The estimated cost per life-year saved is approximately UK £1000 or US $1500.
  • Common side effects include dry mouth and sleep disturbance; rare serious side effects include anaphylaxis and seizures.

Conclusions:

  • Bupropion hydrochloride sustained-release is a first-line smoking cessation treatment.
  • It is cost-effective in saving life-years.
  • Contraindications and precautions, including seizure risk, must be considered.
  • Combining medication with behavioral support enhances cessation success.