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Related Experiment Videos

Current treatments for scabies.

M Buffet1, N Dupin

  • 1Service de Dermato-Vénéréologie, Groupe Hospitalier Cochin, Pavillon Tarnier - Hôpital Cochin, 89, rue d'Assas, 75006 Paris, France.

Fundamental & Clinical Pharmacology
|April 2, 2003
PubMed
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Scabies treatment options, including topical agents and systemic ivermectin, are reviewed. Evidence for the best topical treatment is limited, but ivermectin shows promise for specific cases like HIV-positive patients and institutional outbreaks.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Parasitology

Background:

  • Scabies is a common human ectoparasitic infection with various available treatments.
  • Systemic ivermectin, an antiparasitic agent, is increasingly studied for scabies.
  • Evidence-based medicine is crucial for determining optimal scabies treatment strategies.

Purpose of the Study:

  • To determine the preferred treatment for common scabies in healthy individuals.
  • To clarify the role and efficacy of systemic ivermectin in scabies management.
  • To review literature on scabies treatments using an evidence-based approach.

Main Methods:

  • Literature review utilizing an evidence-based medicine methodology.
  • Analysis of controlled studies and open studies on topical and systemic treatments.

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  • Focus on efficacy, safety, and specific patient populations.

    • Main Results:

    • Topical treatments (permethrin, benzyl benzoate, lindane, crotamiton) show heterogeneous efficacy; permethrin 5% cream is well-studied.
    • Systemic ivermectin demonstrates efficacy in common scabies and specific situations like institutional outbreaks and HIV-positive patients.
    • Comparative studies between leading topical treatments and systemic ivermectin are limited.

    Conclusions:

    • The optimal topical treatment for common scabies remains undetermined due to limited high-quality comparative studies.
    • Systemic ivermectin is indicated for common scabies and likely beneficial for HIV-positive patients and institutional epidemics.
    • Treatment decisions should be individualized, considering feasibility, and contact tracing is essential.