Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular failure: a hypothesis.

Stephen M Schwartz1, Randolph L Geary, Lawrence D Adams

  • 1Department of Pathology, I-420 HSB, University of Washington School of Medicine, Seattle, WA 98195-7335, USA. schwartzs@u.washington.edu

Current Atherosclerosis Reports
|April 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk of Head and Neck Cancer in Former Smokers by Subsite: A Multicenter Analysis From the INHANCE Consortium.

International journal of cancer·2026
Same author

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors.

Andrology·2026
Same author

Perspective of Hispanic Cancer Survivors on Survivorship Care Plans: A Qualitative Study.

Journal of immigrant and minority health·2025
Same author

Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study.

American journal of human genetics·2025
Same author

Enhancing survivorship care among Hispanic/Latino cancer survivors via lay health educators: results of a pilot randomized trial.

Journal of cancer survivorship : research and practice·2025
Same author

Historical redlining and survival among children, adolescents, and young adults with cancer diagnosed between 2000-2019 in Seattle and Tacoma, Washington.

Cancer·2025

Vascular failure, unlike cardiac failure, is not well-defined. This study proposes that arterial failure, involving vessel mass and function, shares pathways with cardiac failure, leading to conditions like hypertension and atherosclerosis.

Area of Science:

  • Cardiovascular Science
  • Vascular Biology
  • Pathophysiology

Background:

  • Cardiac failure is extensively studied, but vascular failure lacks a clear definition.
  • Vascular failure, particularly arterial failure, has significant but distinct consequences compared to cardiac failure.
  • Understanding normal vascular remodeling is crucial for identifying failure mechanisms.

Purpose of the Study:

  • To propose 'arterial failure' as a recognizable term.
  • To explore the parallels between cardiac and vascular failure pathways.
  • To investigate the consequences of impaired vascular remodeling, such as hypertension and atherosclerosis.

Main Methods:

  • Literature review of normal vascular remodeling.
  • Comparative analysis of pathways involved in cardiac and vascular failure.

Related Experiment Videos

  • Conceptual framework development for arterial failure.

    • Main Results:

    • Arterial failure involves the vessel's inability to control mass, contractile capacity, and lumen.
    • Failure in mass and diameter control can lead to hypertension and atherosclerosis.
    • Pathways similar to cardiac failure may be involved in arterial dysfunction.

    Conclusions:

    • Arterial failure is a critical concept that warrants further research.
    • Understanding vascular remodeling failure is key to addressing hypertension and atherosclerosis.
    • Further research should focus on the molecular and cellular mechanisms underlying arterial failure.