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p53 and apoptosis: it's not just in the nucleus anymore
1Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA.
Molecular Cell
|April 2, 2003
Abstract:
The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.