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Related Experiment Videos

Delusions of alien control in the normal brain.

S-J Blakemore1, D A Oakley, C D Frith

  • 1Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK. s.blakemore@ucl.ac.uk

Neuropsychologia
|April 2, 2003
PubMed
Summary

Hypnosis induced a sense of alien control in healthy individuals by altering brain activity. This suggests that overactivation in the cerebellar-parietal network may underlie delusions of control in schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Delusions of alien control, or passivity experiences, are key symptoms in schizophrenia.
  • These symptoms involve misattributing self-generated actions to external sources.

Purpose of the Study:

  • To investigate the neural correlates of misattributing self-generated movements to an external source using hypnosis in healthy individuals.
  • To compare brain activity during self-attributed versus externally attributed movements.

Main Methods:

  • Hypnosis was used to induce a misattribution of self-generated movement in healthy participants.
  • Positron Emission Tomography (PET) was used to measure brain activity during active movements.
  • Brain activity was compared between movements correctly attributed to the self and those misattributed to an external source.

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Main Results:

  • Active movements misattributed to an external source showed significantly higher activations in the parietal cortex and cerebellum compared to self-attributed movements.
  • Hypnotic suggestion altered the functioning of the cerebellar-parietal network.

Conclusions:

  • The findings suggest that altered functioning of the cerebellar-parietal network may lead to the experience of self-produced actions as external.
  • Overactivation of this network could be implicated in the brain mechanisms underlying delusions of control in schizophrenia.