Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Constant mineralization density distribution in cancellous human bone.

P Roschger1, H S Gupta, A Berzlanovich

  • 1Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital & UKH-Meidling, Vienna, Austria. roschger@ap.univie.ac.at

Bone
|April 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Romosozumab in patients who experienced an on-study fracture: post hoc analyses of the FRAME and ARCH phase 3 trials.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2024
Same author

Comparative effectiveness and cardiovascular safety of abaloparatide and teriparatide in postmenopausal women new to anabolic therapy: A US administrative claims database study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Teriparatide and pelvic fracture healing: a phase 2 randomized controlled trial.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Early changes in bone turnover and bone mineral density after discontinuation of long-term oral bisphosphonates: a post hoc analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Staggered Fibrils and Damageable Interfaces Lead Concurrently and Independently to Hysteretic Energy Absorption and Inhomogeneous Strain Fields in Cyclically Loaded Antler Bone.

ACS biomaterials science & engineering·2021

Bone mineralization density distribution (BMDD) is remarkably consistent in healthy adults across various factors. Quantitative backscattered electron imaging (qBEI) can detect subtle changes in bone mineralization due to disease or treatment.

Area of Science:

  • Bone biology and biomechanics
  • Skeletal tissue analysis
  • Mineralization processes

Background:

  • Bone matrix mineralization is crucial for mechanical strength.
  • Bone remodeling and mineralization create a characteristic bone mineralization density distribution (BMDD).
  • Understanding BMDD variance is key to interpreting bone health.

Purpose of the Study:

  • To investigate the biological variance of BMDD at the micrometer level.
  • To establish reference BMDD values for healthy adult humans.
  • To assess the utility of quantitative backscattered electron imaging (qBEI) for detecting mineralization changes.

Main Methods:

  • Quantitative backscattered electron imaging (qBEI) was applied to bone samples.
  • BMDD was characterized using mean calcium concentration (Ca(Mean)), peak calcium concentration (Ca(Peak)), and Ca(Width).

Related Experiment Videos

  • Analysis included factors like ethnicity, skeletal site, age, gender, and disease status.

    • Main Results:

    • No statistically significant differences in BMDD parameters were found based on ethnicity, skeletal site, age, or gender.
    • Interindividual variance in Ca(Mean) and Ca(Peak) was very small (SD < 2.1% of means).
    • Significant BMDD changes were observed in bone diseases (e.g., osteomalacia) and after treatments (e.g., alendronate).

    Conclusions:

    • BMDD is largely constant in healthy adult humans, irrespective of biological variations.
    • qBEI is a sensitive method for detecting alterations in bone mineralization.
    • Transiliac biopsies can represent skeletal-wide cancellous bone BMDD, aiding disease diagnosis and treatment monitoring.