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Adrenomedullin and cancer
E Zudaire1, A Martínez, F Cuttitta
1Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda MD 20892, USA. zudairee@mail.nih.gov
Regulatory Peptides
|April 2, 2003
Summary
Adrenomedullin (AM) is a hormone involved in various diseases, including cancer. This study highlights AM
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Adrenomedullin (AM) is a pluripotent hormone with diverse physiological effects.
- AM shares structural similarities with calcitonin gene-related peptide (CGRP).
- AM is implicated in various pathologies, notably cardiovascular disorders, sepsis, inflammation, diabetes, and cancer.
Purpose of the Study:
- To investigate the role of Adrenomedullin (AM) in cancer progression.
- To explore AM's function in tumor microenvironments, particularly under hypoxia.
- To identify AM's autocrine loop as a potential therapeutic target for human cancers.
Main Methods:
- Review of existing literature on Adrenomedullin (AM) and its role in carcinogenesis.
- Analysis of AM's expression and function in various tumor types.
- Examination of AM's interaction with hypoxia-inducible factor 1 (HIF-1) and its angiogenic properties.
Main Results:
- AM is expressed in various tumors, promoting malignant cell growth and aggressive phenotypes.
- AM acts as an apoptosis survival factor for cancer cells.
- AM is upregulated under hypoxia via HIF-1, promoting angiogenesis and tumor neovascularization.
- AM indirectly suppresses immune response through complement factor H and cytokine regulation.
Conclusions:
- Adrenomedullin (AM) is a significant regulator of carcinogenesis and tumor progression.
- AM's role in promoting tumor growth, survival, and angiogenesis makes it a key factor in cancer development.
- Targeting the AM autocrine loop presents a promising strategy for novel anti-cancer therapies.