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Updated: Jul 15, 2026
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A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines
Jean Yves Winum1, Jean Luc Bouissière, Isabelle Passagne
1Laboratoire de chimie biomoléculaire, UMR 5032, Université Montpellier II-CNRS-laboratoires Mayoly Spindler, ENSCM, 8, rue de l'Ecole Normale, 34296 cedex, Montpellier, France. winumj@univ-montp2.fr
European Journal of Medicinal Chemistry
|April 2, 2003
Abstract:
Two new analogues of Fotemustine have been synthesized and tested on two melanoma cell lines. Compounds 4 and 8 proved to be more potent than the reference compound on A375 cell line which express the MGMT enzyme involved in the chemoresistance of tumoral cells.
