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Zinc fingers and a green thumb: manipulating gene expression in plants
David J Segal1, Justin T Stege, Carlos F Barbas
1The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Current Opinion in Plant Biology
|April 2, 2003
Abstract:
Artificial transcription factors can be rapidly constructed from predefined zinc-finger modules to regulate virtually any gene. Stable, heritable up- and downregulation of endogenous genes has been demonstrated in transgenic plants. These advances promise new approaches for creating functional knockouts and conditional overexpression, and for other gene discovery and manipulation applications in plants.