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Peptide nucleic acid-metal complex conjugates: facile modulation of PNA-DNA duplex stability
Andriy Mokhir1, Roman Stiebing, Roland Kraemer
1Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, Germany.
Bioorganic & Medicinal Chemistry Letters
|April 2, 2003
Abstract:
Conjugates of peptide nucleic acids (PNA) and metal binding ligands were prepared using solid-phase synthesis. Stability of duplexes of bis-picolylamine-PNA conjugates and DNA was found to be modulated by equimolar concentrations of bioavailable metal ions: Ni(2+), Zn(2+)>Cu(2+). Sequence specificity of PNA was not compromised in the presence of these metal ions.