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Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation
Shuzhang Yang1, Yukio Kawamura, Masaaki Yoshikawa
1Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, 611-0011, Kyoto, Japan.
Abstract:
Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroventricular administration, and at 100mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the delta antagonist naltrindole, suggesting the involvement of the delta opioid receptor.