Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent arterial thrombosis in nephrosis.

R A Parrish, R B Scurry, A F Robertson

    American Journal of Diseases of Children (1960)
    |April 1, 1976
    PubMed
    Summary

    Nephrotic syndrome in children can lead to arterial thrombosis, a serious condition causing blood clots. Hypovolemia and steroid therapy may increase clotting risk in these patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diagnostic accuracy of 3-T magnetic resonance imaging with 3D T1 VIBE versus computer tomography in pars stress fracture of the lumbar spine.

    Skeletal radiology·2016
    Same author

    Conviviality in Catalonia.

    Gastronomica : the journal of food and culture·2011
    Same author

    General discussion.

    Bulletin of the New York Academy of Medicine·2009
    Same author

    Comparison of the bilirubin concentration and the bilirubin/albumin ration with the bilirubin-binding ability in neonatal serum.

    The Journal of pediatrics·1998
    Same author

    Zygomycosis in neonates.

    The Pediatric infectious disease journal·1997
    Same author

    Effects of glucose or insulin infusions on growth hormone secretion in male red deer.

    General and comparative endocrinology·1996

    Area of Science:

    • Pediatric Nephrology
    • Vascular Surgery
    • Hematology

    Background:

    • Nephrotic syndrome is a kidney disorder characterized by protein in the urine, edema, and low blood protein levels.
    • Arterial thrombosis, or blood clot formation in arteries, is a rare but severe complication in pediatric nephrotic syndrome.
    • Long-term steroid therapy is a common treatment for nephrotic syndrome, but may have associated risks.

    Observation:

    • An 8-year-old boy with nephrotic syndrome experienced recurrent arterial thrombosis without apparent cause.
    • The patient developed thrombosis in the left femoral artery and subsequently required amputation of the right leg.
    • Hypovolemia was noted in the child during long-term steroid therapy.

    Findings:

    • Early thrombectomy and anticoagulation successfully managed left femoral artery thrombosis.
    • The patient's condition ultimately led to the amputation of the right leg.
    • Hypovolemia in nephrotic children on steroids appears to promote a hypercoagulable state.

    Implications:

    • This case highlights the critical risk of arterial thrombosis in pediatric nephrotic syndrome.
    • Management strategies should consider the prothrombotic tendency associated with hypovolemia and steroid use.
    • Further research is needed to elucidate the mechanisms linking nephrotic syndrome, hypovolemia, steroid therapy, and hypercoagulability in children.

    Related Experiment Videos