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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 13, 2011
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Dobutamine cardiovascular magnetic resonance for the detection of myocardial ischemia with the use of myocardial
Dirkjan Kuijpers1, Kai Yiu J A M Ho, Paul R M van Dijkman
1Department of Radiology, University Hospital Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands. kps@xs4all.nl
Circulation
|April 2, 2003
Summary
High-dose dobutamine cardiovascular magnetic resonance (CMR) with myocardial tagging improves detection of new wall motion abnormalities for diagnosing coronary artery disease. This method reliably identifies patients with normal life expectancy versus those at increased cardiac risk.
Area of Science:
- Cardiovascular Imaging
- Diagnostic Cardiology
- Medical Technology
Background:
- Coronary artery disease (CAD) diagnosis often relies on detecting myocardial ischemia.
- Wall motion abnormalities (WMAs) are key indicators of myocardial ischemia.
- Assessing WMAs in CAD patients requires sensitive and reliable imaging techniques.
Purpose of the Study:
- To evaluate the diagnostic value of high-dose dobutamine cardiovascular magnetic resonance (CMR) with myocardial tagging.
- To determine if myocardial tagging enhances the detection of WMAs compared to standard dobutamine-CMR.
- To assess the utility of dobutamine-CMR in identifying myocardial ischemia in patients with known or suspected CAD.
Main Methods:
- Dobutamine-CMR was performed in 211 patients with chest pain after medication withdrawal.
- Cine-images with and without myocardial tagging were acquired at rest and during dobutamine infusion.
- Regional wall motion was analyzed using a 16-segment model; patients with new WMAs (NWMA) underwent coronary angiography.
Main Results:
- Dobutamine-CMR was successful in 194 patients.
- Myocardial tagging detected significantly more NWMA (68 patients) compared to standard dobutamine-CMR (58 patients; P=0.002).
- Coronary angiography confirmed CAD in 96% of patients with NWMA, with most requiring revascularization; 98.2% cardiovascular event-free survival in negative studies.
Conclusions:
- Dobutamine-CMR with myocardial tagging offers superior detection of NWMA compared to dobutamine-CMR without tagging.
- This enhanced imaging technique reliably differentiates patients with normal prognosis from those at high risk for adverse cardiac events.
- Myocardial tagging in dobutamine-CMR is a valuable tool for diagnosing myocardial ischemia in suspected CAD.
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