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Related Experiment Videos

Digoxin tablets--a review of the bioavailability problems.

S K Sim

    American Journal of Hospital Pharmacy
    |January 1, 1976
    PubMed
    Summary

    Recent studies reveal significant variations in digoxin tablet bioavailability, impacting therapeutic effectiveness. While dissolution testing is a common predictor, its correlation with actual bioavailability is not always reliable.

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    Area of Science:

    • Pharmaceutical Sciences
    • Pharmacokinetics
    • Drug Product Quality

    Background:

    • Digoxin tablet bioavailability is crucial for therapeutic efficacy.
    • Commercial digoxin tablets exhibit variability in bioavailability.
    • Existing pharmacopeial standards for content uniformity do not guarantee bioavailability uniformity.

    Purpose of the Study:

    • To review recent bioavailability studies on digoxin tablets.
    • To identify variations among commercially available digoxin tablets.
    • To evaluate the correlation between in vitro dissolution and in vivo bioavailability.

    Main Methods:

    • Review of recent scientific literature on digoxin bioavailability.
    • Analysis of data from bioavailability and dissolution studies.
    • Comparison of pharmacopeial requirements with study findings.

    Main Results:

    • Significant variations in digoxin tablet bioavailability were identified.
    • In vitro dissolution rate generally correlates with in vivo bioavailability, but exceptions exist.
    • Pharmacopeial content uniformity does not ensure bioavailability uniformity.

    Conclusions:

    • Digoxin tablet bioavailability is variable and impacts clinical outcomes.
    • In vitro dissolution testing is a useful but not infallible predictor of bioavailability.
    • Further research and regulatory attention are needed to ensure consistent digoxin bioavailability.

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