Anti-silencing from the core: a histone H2A variant protects euchromatin

High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.

Nucleic acids research·2025

dCas9-mediated dysregulation of gene expression in human induced pluripotent stem cells during primitive streak differentiation.

Metabolic engineering·2022

DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.

ACS chemical biology·2022

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.

Nature communications·2022

Engineering digitizer circuits for chemical and genetic screens in human cells.

Nature communications·2021

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.

Cell chemical biology·2021

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Nature cell biology·2026

Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia.

Nature cell biology·2026

Advanced imaging of membrane contact sites.

Nature cell biology·2026

Mega-enhancers compartmentalize transcriptionally active long genes in the brain.

Nature cell biology·2026

The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation.

Nature cell biology·2026

Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis.

Nature cell biology·2026

CamK-DB: A k-mer MinHash fingerprint database for reference-free genotyping of Camellia accessions.

GigaScience·2026

Study on the role of miR-433-3p in the occurrence and development of endometriosis.

Nucleosides, nucleotides & nucleic acids·2026

Heat-responsive ONSEN long terminal repeats integrate heat shock factor motifs, DNA methylation and natural sequence variation in Arabidopsis.

Biology open·2026

Insights into the recruitment of the H3K4me3 reader Spp1 by the meiotic double-strand break protein Mer2.

Nucleic acids research·2026

Newly synthesized histones: passive or active players in the regulation of epigenetic inheritance?

Nucleic acids research·2026

Epigenetic and Metabolic Regulation of Macrophages during Gout.

Gout, urate, and crystal deposition disease·2026

Related Experiment Videos

Anti-silencing from the core: a histone H2A variant protects euchromatin

Related Concept Videos

High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.

dCas9-mediated dysregulation of gene expression in human induced pluripotent stem cells during primitive streak differentiation.

DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.

Engineering digitizer circuits for chemical and genetic screens in human cells.

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia.

Advanced imaging of membrane contact sites.

Mega-enhancers compartmentalize transcriptionally active long genes in the brain.

The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation.

Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis.

CamK-DB: A k-mer MinHash fingerprint database for reference-free genotyping of Camellia accessions.

Study on the role of miR-433-3p in the occurrence and development of endometriosis.

Heat-responsive ONSEN long terminal repeats integrate heat shock factor motifs, DNA methylation and natural sequence variation in Arabidopsis.

Insights into the recruitment of the H3K4me3 reader Spp1 by the meiotic double-strand break protein Mer2.

Newly synthesized histones: passive or active players in the regulation of epigenetic inheritance?

Epigenetic and Metabolic Regulation of Macrophages during Gout.

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Anti-silencing from the core: a histone H2A variant protects euchromatin

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