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Related Experiment Videos

Glycerol and hyperosmolar nonketotic coma.

D E Oakley, P P Ellis

    American Journal of Ophthalmology
    |April 1, 1976
    PubMed
    Summary

    Oral glycerol use can trigger hyperosmolar nonketotic coma in diabetic patients with kidney failure. Prompt treatment with fluids, blood products, insulin, and bicarbonate successfully reversed this dangerous complication.

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    Area of Science:

    • Nephrology
    • Endocrinology
    • Ophthalmology

    Background:

    • Diabetic patients with chronic renal failure are at risk for metabolic complications.
    • Neovascular glaucoma treatment sometimes involves agents that can affect fluid and electrolyte balance.

    Observation:

    • A 29-year-old diabetic man with chronic renal failure developed hyperosmolar nonketotic coma.
    • This complication followed repeated oral glycerol administration for acute neovascular glaucoma.

    Findings:

    • The patient's coma was successfully treated with intravenous hypotonic saline, albumin, and packed red blood cells.
    • Concurrent insulin and bicarbonate administration was crucial for metabolic correction.

    Implications:

    • Highlights the potential risk of oral glycerol in susceptible patients.
    • Emphasizes the importance of careful medication management in patients with diabetes and renal failure.
    • Demonstrates effective therapeutic strategies for managing hyperosmolar nonketotic coma.

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