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Factor X deficiency in a Jack Russell terrier.
Audrey K. Cook1, Linda L. Werner, Sharron L. O'Neill
1Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616.
Veterinary Clinical Pathology
|January 1, 1993
Summary
Factor X deficiency, a bleeding disorder, was diagnosed in a Jack Russell Terrier. This is the first documented case in this breed, with affected relatives also identified.
Area of Science:
- Veterinary Medicine
- Hematology
- Canine Genetics
Background:
- Factor X deficiency (Stuart-Prower factor deficiency) is a rare inherited bleeding disorder.
- Previous cases have been documented in American Cocker Spaniels, suggesting an autosomal dominant inheritance pattern.
Purpose of the Study:
- To report the first case of Factor X deficiency in a Jack Russell Terrier.
- To investigate the familial occurrence of Factor X deficiency in this breed.
Main Methods:
- Clinical case presentation of a 7-month-old Jack Russell Terrier with recurrent bleeding.
- Screening of affected dog's relatives for Factor X levels.
Main Results:
- Factor X deficiency was confirmed in the Jack Russell Terrier.
- Low and subnormal Factor X levels were identified in the father and paternal grandmother, respectively.
- This represents the first description of Factor X deficiency in the Jack Russell Terrier breed.
Conclusions:
- Factor X deficiency can occur in Jack Russell Terriers.
- The familial screening suggests a potential inherited basis for the coagulopathy in this breed.
- Further studies are warranted to understand the inheritance pattern and prevalence in Jack Russell Terriers.