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Chronic pulmonary aspergillosis: current classification and therapy
Gianfranco F Schiraldi1, Giovanni Gramegna, Castrenzina De Rosa
1Pneumology Department, Niguarda Ca'Granda Hospital, Piazza Ospedale Maggiore 3, 20162 Milano, Italy. giaschir@tin.it
Current Opinion in Investigational Drugs (London, England : 2000)
|April 3, 2003
Summary
This review proposes "chronic pulmonary aspergillosis" as a unified term for non-acute lung aspergillosis. It analyzes existing literature and a terbinafine study, suggesting further research.
Area of Science:
- Pulmonology
- Mycology
- Infectious Diseases
Background:
- Non-acute pulmonary aspergillosis has had varied terminology since the 1980s.
- Previous classifications often depended on predisposing conditions.
- This created terminological uncertainty in the field.
Purpose of the Study:
- To propose a simplified and unified term: 'chronic pulmonary aspergillosis'.
- To introduce a classification system based on pulmonary anatomy.
- To review the classification, diagnosis, and treatment of pulmonary aspergillosis.
Main Methods:
- Comprehensive literature review of Medline and Embase indexed papers (1966-present).
- Analysis of classification, diagnosis, and treatment strategies.
- Inclusion of an open-label study on 23 patients treated with terbinafine.
Main Results:
- Identified terminological inconsistencies in the literature.
- Presented a proposed classification based on anatomical considerations.
- Reported preliminary outcomes from a terbinafine treatment study.
Conclusions:
- The term 'chronic pulmonary aspergillosis' offers clarity.
- Anatomical classification aids in understanding the disease spectrum.
- Further randomized controlled trials are needed to validate treatment efficacy, including terbinafine.