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Chronic pulmonary aspergillosis: current classification and therapy

Gianfranco F Schiraldi1, Giovanni Gramegna, Castrenzina De Rosa

  • 1Pneumology Department, Niguarda Ca'Granda Hospital, Piazza Ospedale Maggiore 3, 20162 Milano, Italy. giaschir@tin.it

Current Opinion in Investigational Drugs (London, England : 2000)
|April 3, 2003
PubMed

Insights

This review proposes "chronic pulmonary aspergillosis" as a unified term for non-acute lung aspergillosis. It analyzes existing literature and a terbinafine study, suggesting further research.

Area of Science:

  • Pulmonology
  • Mycology
  • Infectious Diseases

Background:

  • Non-acute pulmonary aspergillosis has had varied terminology since the 1980s.
  • Previous classifications often depended on predisposing conditions.
  • This created terminological uncertainty in the field.

Purpose of the Study:

  • To propose a simplified and unified term: 'chronic pulmonary aspergillosis'.
  • To introduce a classification system based on pulmonary anatomy.
  • To review the classification, diagnosis, and treatment of pulmonary aspergillosis.

Main Methods:

  • Comprehensive literature review of Medline and Embase indexed papers (1966-present).
  • Analysis of classification, diagnosis, and treatment strategies.
  • Inclusion of an open-label study on 23 patients treated with terbinafine.

Main Results:

  • Identified terminological inconsistencies in the literature.
  • Presented a proposed classification based on anatomical considerations.
  • Reported preliminary outcomes from a terbinafine treatment study.

Conclusions:

  • The term 'chronic pulmonary aspergillosis' offers clarity.
  • Anatomical classification aids in understanding the disease spectrum.
  • Further randomized controlled trials are needed to validate treatment efficacy, including terbinafine.

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