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Related Experiment Videos

Cyclodextrin nephrosis in the rat.

D W Frank, J E Gray, R N Weaver

    The American Journal of Pathology
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Schardinger dextrins, like alpha and beta-cyclodextrin, cause kidney toxicity by damaging vacuolar organelles in proximal tubules. This leads to giant lysosomes and cell death, highlighting the vacuolar apparatus

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    Area of Science:

    • Nephrology
    • Toxicology
    • Cell Biology

    Background:

    • Schardinger dextrins, including alpha- and beta-cyclodextrins, are known to induce renal toxicity.
    • The proximal convoluted tubule is the primary site of observed toxic alterations.
    • Vacuolar organelles are implicated in the mechanism of cyclodextrin-induced nephropathy.

    Purpose of the Study:

    • To investigate the specific alterations in vacuolar organelles induced by Schardinger dextrins in the proximal convoluted tubule.
    • To elucidate the role of the vacuolar apparatus in the pathogenesis of cyclodextrin nephrosis.
    • To understand the cellular mechanisms underlying cyclodextrin toxicity in renal cells.

    Main Methods:

    • Light microscopy was used to observe cellular changes in the proximal convoluted tubule.

    Related Experiment Videos

  • Histochemical staining was employed to assess the activity of acid phosphatase within lysosomes.
  • Ultrastructural analysis was performed to examine the morphology of organelles, including vacuoles, lysosomes, and mitochondria.

    • Main Results:

    • Increased apical vacuoles and the formation of giant lysosomes containing acicular microcrystals were observed.
    • Advanced lesions showed giant vacuoles devoid of acid phosphatase activity.
    • Significant changes in the vacuolar apparatus preceded damage to mitochondria and other organelles.

    Conclusions:

    • The vacuolar apparatus plays a critical role in the development of cyclodextrin nephrosis.
    • Intracellular accumulation of cyclodextrins via the lysosomal pathway represents a toxic mechanism.
    • This process disrupts normal proximal tubule function, ultimately leading to cell death.