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Related Experiment Videos

Direct methods for modulating protein function.

Leodevico L Ilag1

  • 1Xerion Pharmaceuticals AG, Fraunhoferstrasse 9, 82152 Martinsried, Germany. l.ilag@xerion-pharma.com

Current Opinion in Drug Discovery & Development
|April 3, 2003
PubMed
Summary
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The drug discovery field is moving towards biology, identifying proteins as key targets. New methods are emerging to directly test these protein targets for drug development potential.

Area of Science:

  • Genomics and Proteomics
  • Pharmacology
  • Biotechnology

Background:

  • The drug discovery paradigm has shifted from chemistry-based to biology-driven approaches.
  • Genome sciences have identified numerous proteins as potential drug targets.
  • Current methods for target validation are insufficient for direct pharmacological intervention.

Purpose of the Study:

  • To highlight the shift towards biology-driven drug discovery.
  • To emphasize the need for direct protein target modulation technologies.
  • To discuss the role of new technologies in post-genomic drug development.

Main Methods:

  • Review of current trends in drug discovery.
  • Discussion of genome sciences' contribution to target identification.

Related Experiment Videos

  • Exploration of direct protein modulation technologies: chemical genetics, analog-sensitive enzyme alleles, and chromophore-assisted laser inactivation.

    • Main Results:

    • Proteins are the primary targets in the post-genomic era.
    • Direct methods are crucial for assessing protein target suitability.
    • Emerging technologies offer novel ways to modulate protein activity.

    Conclusions:

    • The field requires direct methods to validate protein targets for drug discovery.
    • Technologies like chemical genetics and chromophore-assisted laser inactivation are vital for post-genomic drug development.
    • A shift to biology-driven discovery necessitates advanced tools for protein target characterization and modulation.