[Antihomotoxic drug therapy of endothelial function disorder in patients with hypertension]

Area of Science:

• Cardiovascular Medicine
• Pharmacology
• Integrative Medicine

Context:

• Hypertensive disease affects vascular function, impacting blood flow regulation.
• Endothelial dysfunction is a key feature of hypertension, contributing to cardiovascular risk.
• Antihomotoxic preparations are used as complementary therapy in managing hypertensive conditions.

Purpose:

• To evaluate the efficacy of a multimodality therapy involving conventional treatment and antihomotoxic drugs (Hepar compositum, Ubichinon compositum) in patients with hypertensive disease.
• To assess the impact of this therapy on post-ischemic vascular responses and endothelial function.
• To determine if the therapy normalizes vascular responsiveness to ischemic stimuli and nitroglycerin.

Summary:

• A multimodality therapy combining conventional treatment with antihomotoxic preparations (Hepar compositum, Ubichinon compositum) was administered to patients with hypertensive disease.
• The therapy promoted the restoration of initial post-ischemic vasoconstriction but did not normalize overall vascular responsiveness to ischemia or nitroglycerin.
• Importantly, the antihomotoxic drugs optimized endothelial function, normalizing parameters of initial post-ischemic vasoconstriction and maximum post-ischemic vasodilation.

Impact:

• This study suggests that antihomotoxic preparations may play a role in improving endothelial function in hypertensive patients.
• The findings highlight the potential of complementary therapies in managing vascular aspects of hypertensive disease.
• Further research is warranted to fully elucidate the mechanisms and long-term effects of antihomotoxic therapy on vascular health in hypertension.