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[Interrelationship between autonomic regulation and systolic function of left ventricular in patient with

A V Bil'chenko

    Likars'Ka Sprava
    |April 3, 2003
    PubMed

    Insights

    Hypertensive disease (HD) patients with reduced systolic function show poorer heart rhythm variability, indicating an unfavorable prognosis linked to sympathetic nervous system decline. Compensatory reserves were noted in some patients.

    Area of Science:

    • Cardiology
    • Autonomic Nervous System Physiology

    Context:

    • Hypertensive disease (HD) affects cardiovascular autonomic regulation.
    • Systolic dysfunction is a critical concern in HD management.

    Purpose:

    • To investigate the relationship between systolic function and autonomic regulation in HD patients.
    • To identify prognostic indicators related to autonomic dysfunction in HD.

    Summary:

    • A study of 176 HD patients revealed a correlation between declined systolic function and reduced heart rate variability.
    • This decline is associated with unfavorable prognosis and increased sympathetic nervous system activity.
    • Tilt-test responses indicated compensatory mechanisms in the humoral and sympathetic systems in patients with reduced systolic function.

    Impact:

    • Findings highlight the importance of assessing autonomic function for prognosis in hypertensive disease.
    • Suggests potential therapeutic targets within the autonomic nervous system for managing HD.
    • Provides insights into the complex interplay between cardiac function and neuro-autonomic control in hypertension.

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