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Updated: Jul 30, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
[Functional changes in hematopoiesis in healthy subjects during adaptation to a high altitude hypoxia]
E A Muratalieva1, S M Mamatov, A K Nartaeva
1Kirgyz Cientific Centre of Haematology, Kirgyzstan.
Abstract:
In the article, findings of the studies of white blood in healthy subjects during a short-term adaptation to high altitude (per. Tuya-Ashu, 3200 m), are discussed. A 40-day adaptation of healthy people has led to positive shifts: an increase of the number of leukocytes with prevalence of the absolute count of neutrophiles and lymphocytes, as well as an activation of the latter during the first days of stay at high altitude. An effect of the high-altitude hypoxia resulted in intensification of erythropoiesis that manifests itself in an improvement of red cell hemoglobinization and a decrease of the degree of non-effective erythropoiesis. The data obtained support the data of the myelograms demonstrating an improvement of differentiation of white hematopoiesis.
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