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Fatal acute poisoning by bentazon.
A Turcant1, P Harry, A Cailleux
1Laboratoire de Pharmacologie-Toxicologie, CHU, 4 rue Larrey, 49033 Angers, France.
Journal of Analytical Toxicology
|April 3, 2003
Summary
This case report details a fatal bentazon poisoning incident, highlighting its high toxicity and rapid onset of severe symptoms like muscle rigidity. Analytical methods confirmed high bentazon levels in blood and urine, crucial for understanding herbicide toxicity.
Area of Science:
- Forensic Toxicology
- Clinical Chemistry
- Environmental Health
Background:
- Bentazon is a widely used herbicide.
- Understanding bentazon toxicity is crucial for public health and occupational safety.
- Limited data exists on fatal bentazon poisoning in humans.
Observation:
- A 56-year-old farmer ingested 500 mL of bentazon herbicide.
- The patient developed severe muscle rigidity, respiratory distress, and heart failure within 2 hours.
- Tracheal intubation was impossible due to extreme muscle rigidity.
Findings:
- Blood and urine analysis confirmed high levels of bentazon (1500 mg/L plasma, 1000 mg/L urine).
- Analytical methods included HPLC-DAD and GC-NPD, with specific ion monitoring for bentazon and its metabolites.
- An hydroxylated metabolite and an N1-glucuronide conjugate were identified in urine.
Implications:
- This case demonstrates the high acute toxicity of bentazon following massive ingestion.
- Severe muscle rigidity may be a key indicator of bentazon-induced toxicity.
- Further research into bentazon's toxicological mechanisms and human health effects is warranted.