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Extrapyramidal side effects in lithium maintenance therapy.

M H Branchey, J Charles, G M Simpson

    The American Journal of Psychiatry
    |April 1, 1976
    PubMed
    Summary
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    Lithium therapy is commonly used for mood stabilization. A study found few patients on lithium maintenance developed mild parkinson-like side effects, specifically rigidity.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Psychiatry

    Background:

    • Lithium is a widely prescribed mood stabilizer.
    • Previous reports suggest a high incidence of parkinson-like side effects, such as cogwheel rigidity, in patients on long-term lithium therapy.

    Purpose of the Study:

    • To investigate the occurrence and severity of parkinson-like side effects in patients undergoing long-term lithium maintenance therapy.

    Main Methods:

    • Neurological examination of 36 patients on lithium therapy for 6 months to 7 years.
    • Assessment of specific symptoms including rigidity and cogwheel rigidity.

    Main Results:

    • Only a small subset of patients exhibited rigidity.
    • The observed rigidity was generally of mild severity.

    Related Experiment Videos

  • Cogwheel rigidity was infrequent and mild in the examined patient group.

    • Conclusions:

    • The findings do not corroborate previous reports of frequent cogwheel rigidity in patients on lithium maintenance.
    • Long-term lithium therapy may be associated with a lower incidence of parkinson-like side effects than previously suggested.