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A molecular warhead and its target: tissue transglutaminase and Celiac Sprue
Detlef Schuppan1, Walburga Dieterich
1First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany.
Chemistry & Biology
|April 3, 2003
Abstract:
The substitution of a glutamine residue with 6-diazo-5-oxo-norleucine (DON) transforms an immunodominant gluten peptide into a potent inhibitor of tissue transglutaminase. DON-modified peptides could be useful for the study and therapy of celiac sprue.