Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caudal cingulate cortex involvement in pain processing: an inter-individual laser evoked potential source

Deborah E Bentley1, Stuart W G Derbyshire, Paula D Youell

  • 1Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Clinical Sciences Building, Hope Hospital, Salford M6 8HD, UK Department of Anaesthesiology, University of Pittsburgh Medical Centre, 200 Lothrop Street, Pittsburgh, PA 15213, USA Laser Photonics, Department of Physics and Astronomy, Schuster Laboratory, The University of Manchester, Brunswick Street, Manchester M13 9PL, UK.

Pain
|April 3, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic learning of the meaning of information changes pain perception.

Scientific reports·2025
Same author

Peripheral contributions to offset analgesia: effects of stimulus duration, intensity, and location.

Pain·2025
Same author

The Hope and Reality of Pain Relief Using Psychological Manipulations.

Psychosomatic medicine·2024
Same author

Are We Any Closer to Understanding How Chronic Pain Develops? A Systematic Search and Critical Narrative Review of Existing Chronic Pain Vulnerability Models.

Journal of pain research·2023
Same author

A feasibility study of pre-sleep audio and visual alpha brain entrainment for people with chronic pain and sleep disturbance.

Frontiers in pain research (Lausanne, Switzerland)·2023
Same author

Frontal alpha asymmetry: A potential biomarker of approach-withdrawal motivation towards pain.

Frontiers in pain research (Lausanne, Switzerland)·2022
This summary is machine-generated.

This study precisely located the brain source of laser pain evoked potentials (LEPs) using realistic head models. Findings show consistent cingulate cortex involvement in pain processing across individuals.

Area of Science:

  • Neuroscience
  • Pain Perception
  • Electrophysiology

Background:

  • Cingulate cortex is a known source of laser pain evoked potentials (LEPs).
  • Previous studies often lacked detailed anatomical localization due to simplified head models.
  • Individual anatomical variability necessitates realistic head models for accurate source analysis.

Purpose of the Study:

  • To accurately localize the cingulate cortex source of LEPs using subject-specific realistic head models.
  • To assess the inter-individual anatomical variability of this pain processing source.
  • To enhance understanding of the neural basis of acute pain perception.

Main Methods:

  • Laser pain evoked potentials (LEPs) recorded from 62 electrodes in five healthy subjects.
  • Pain stimuli delivered via CO(2) laser to the right forearm.

Related Experiment Videos

  • Dipole source localization performed using CURRY 4.0 software with individual MRI-derived head models.

    • Main Results:

    • The P2 peak of LEPs was consistently explained by a dipole originating in the cingulate cortex (mean residual variance 3.9%).
    • For most subjects, the source localized to the border of left anterior and posterior cingulate cortex (areas 24/32' and 23/31).
    • One subject showed a source in the right posterior cingulate cortex (area 31).

    Conclusions:

    • Realistic head models enable precise anatomical localization of LEP sources.
    • The cingulate source of LEPs demonstrates high inter-individual anatomical consistency.
    • Caudal cingulate regions are strongly implicated in the processing of laser-induced pain.