Related Experiment Video

Updated: Sep 26, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Use of the GlucoWatch biographer in children with type 1 diabetes

H Peter Chase1, Mary D Roberts, Clare Wightman

  • 1Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA.

Pediatrics
|April 3, 2003
PubMed

Insights

The GlucoWatch biographer improved glucose control in children with type 1 diabetes. This device helped detect more hypoglycemia, especially at night, enhancing diabetes management safety.

Area of Science:

  • Pediatric Endocrinology
  • Diabetes Technology
  • Metabolic Disease Management

Background:

  • Type 1 diabetes management in children requires continuous glucose monitoring.
  • Poor glucose control (HbA1c >8%) is common and necessitates improved therapeutic strategies.
  • The GlucoWatch biographer offers a novel approach to glucose monitoring.

Purpose of the Study:

  • To evaluate the efficacy of the GlucoWatch biographer in improving glycemic control in pediatric patients with type 1 diabetes.
  • To assess the safety and tolerability of the GlucoWatch biographer in this population.

Main Methods:

  • A randomized controlled trial involving 40 children with type 1 diabetes and poor glycemic control.
  • Intervention group used the GlucoWatch biographer for 3 months alongside conventional monitoring.
  • HbA1c levels were measured at baseline and at 1, 3, 6, and 9 months.

Main Results:

  • The biographer group showed a significant reduction in HbA1c after 3 months (8.4% vs. 9% in control).
  • Increased detection of hypoglycemia, particularly nocturnal episodes, was observed with biographer use.
  • The device was well-tolerated, with only one case of skin irritation reported.

Conclusions:

  • The GlucoWatch biographer effectively improves glucose control in children and adolescents with type 1 diabetes.
  • The device's alarm feature for nocturnal hypoglycemia enhances the safety of diabetes management.
  • Continuous glucose monitoring technology holds promise for pediatric diabetes care.
Abstract

More Related Videos

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology08:16

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology

Published on: March 15, 2024

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...